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Let's talk about what can happen after using doxycycline since the phrase "doxycycline ruined my life" is frequently searched. Can it result in permanent discoloration? Does it make people think about committing suicide? Does it prevent you from spending time in the sun? These are all pretty typical doxycycline adverse effects. There could have also been other problems. Skin darkening is another adverse effect of doxycycline that can be harmful and even fatal.